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A Phase 2, Open Label, Multiple Center Study to Evaluate the Safety, Tolerability, and Efficacy of CM-101 Administered for 12 Weeks in Adult Subjects with Primary Sclerosing Cholangitis.

EudraCT Number: 2018-004258-77
Sponsor Protocol Number: CM-101-PSC-001
Sponsor Name: ChemomAb Ltd.
Start Date: 2019-02-05
Medical condition: Treatment of Primary Sclerosing Cholangitis
Version: 20.1
SOC Term: 100000004871
Classification Code: 10036732
Term: Primary sclerosing cholangitis
Level: LLT

Population Age: Adults, Elderly
Gender: Male, Female
Trial Protocol: GB (Prematurely Ended)

A prospective international multicenter phase II study to evaluate the efficacy, safety and quality of life of oral daily pazopanib in patients with advanced and/or metastatic renal cell carcinoma ...

EudraCT Number: 2017-000708-10
Sponsor Protocol Number: CPZP034A2410
Sponsor Name: Novartis Pharma AG
Start Date: 2017-09-18
Medical condition: Advanced and/or metastatic renal cell carcinoma
Version: 20.0
SOC Term: 100000004864
Classification Code: 10068208
Term: Renal neoplasms malignant
Level: HLT

Population Age: Adults, Elderly
Gender: Male, Female
Trial Protocol: CZ (Ongoing), DE (Temporarily Halted), ES (Ongoing), AT (Ongoing), GB (Ongoing), HU (Ongoing)

Open label extension study to evaluate the long-term safety and tolerability of dupilumab in patients with asthma who participated in previous dupilumab asthma clinical study

EudraCT Number: 2013-003856-19
Sponsor Protocol Number: LTS12551
Sponsor Name: Sanofi-aventis recherche et développement
Start Date: 2014-05-28
Medical condition: Asthma
Version: 16.1
SOC Term: 10038738 - Respiratory, thoracic and mediastinal disorders
Classification Code: 10003553
Term: Asthma
Level: PT

Population Age: Adults, Elderly
Gender: Male, Female
Trial Protocol: ES (Completed), IT (Ongoing), PL (Ongoing), DE (Completed), GB (Completed), NL (Completed), HU (Completed), BE (Completed), DK (Completed), SE (Completed), Outside EU/EEA

A Proof of Concept Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer
Published: 5 Dec 2019 | 17:00 UTC

Condition:   Breast Cancer
Interventions:   Drug: Avelumab;   Drug: Aspirin;   Drug: Lansoprazole
Sponsors:   The Christie NHS Foundation Trust;   University of Manchester
Not yet recruiting

Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes
Published: 5 Dec 2019 | 17:00 UTC

Condition:   Metastatic or Unresectable Melanoma
Interventions:   Drug: Nivolumab;   Drug: Talazoparib
Sponsor:   Pauline Funchain
Not yet recruiting

A Study to Evaluate the Effect of AZD8154 Administered Via Nebulizer Once Daily in Subjects With Mild Allergic Asthma Challenged With an Inhaled Allergen
Published: 5 Dec 2019 | 17:00 UTC

Condition:   Asthma
Interventions:   Drug: AZD8154 nebulizer suspension, 20 mg/mL;   Drug: Placebo
Sponsors:   AstraZeneca;   Parexel
Not yet recruiting

A Study to Evaluate the Effect of AZD8154 Administered Via Nebulizer Once Daily in Subjects With Mild Allergic Asthma Challenged With an Inhaled Allergen
Published: 5 Dec 2019 | 17:00 UTC

Condition:   Asthma
Interventions:   Drug: AZD8154 nebulizer suspension, 20 mg/mL;   Drug: Placebo
Sponsors:   AstraZeneca;   Parexel
Not yet recruiting

Reducing Knee Compression When Sleeping in Those With Knee OA
Published: 5 Dec 2019 | 17:00 UTC

Condition:   Osteoarthritis, Knee
Interventions:   Behavioral: Change in sleeping position;   Behavioral: No change in sleeping position
Sponsor:   University of Bradford

Aptinyx Initiates Phase 2 Study of NYX-458 in Patients with Mild Cognitive Impairment Associated with Parkinson’s Disease
Published: 5 Dec 2019 | 0:00 UTC

Aptinyx Inc. (Nasdaq: APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of brain and nervous system disorders, today announced the initiation of a Phase 2 clinical study of its novel NMDA receptor modulator, NYX-458, for the treatment of mild cognitive impairment associated with Parkinson’s disease.

American BriVision Initiates Phase II Part I Clinical Trial for ABV-1505 in Adult Attention-Deficit Hyperactivity Disorder (ADHD)
Published: 5 Dec 2019 | 0:00 UTC

PDC-1421, the active ingredient of ABV-1505, is being expanded into adult ADHD trials following encouraging Phase II trial results in major depressive disorder

Regeneron Announces Positive Topline Phase 2 Data with Anti-C5 Antibody Pozelimab in Patients with a Rare Blood Disorder
Published: 5 Dec 2019 | 0:00 UTC

Results from initial 6-patient cohort show pozelimab reduced lactate dehydrogenase (LDH) to normal levels at week 8 in patients with paroxysmal nocturnal hemoglobinuria (PNH), utilizing a weekly subcutaneous dosing regimen

Simvastatin in Uveitis
Published: 3 Dec 2019 | 17:00 UTC

Condition:   Uveitis
Intervention:   Drug: Simvastatin 40mg
Sponsor:   Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology

Pharmacokinetics of Advantage Anti-Caries Varnish
Published: 3 Dec 2019 | 17:00 UTC

Condition:   Dental Caries
Intervention:   Drug: Anti-caries varnish
Sponsors:   Advantage Silver Dental Arrest, LLC;   University of Washington

A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-692 as an Adjunctive Treatment in Adults With Schizophrenia
Published: 11 Nov 2019 | 17:00 UTC

Condition:   Schizophrenia
Interventions:   Drug: CTP-692;   Drug: Placebo
Sponsors:   Concert Pharmaceuticals;   Cognitive Research Corporation

A Study of Cusatuzumab Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy
Published: 17 Jul 2019 | 16:00 UTC

Condition:   Leukemia, Myeloid, Acute
Interventions:   Drug: Azacitidine;   Drug: Cusatuzumab
Sponsors:   Janssen Research & Development, LLC;   argenx BVBA

Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer
Published: 3 May 2019 | 16:00 UTC

Conditions:   Breast Cancer;   DCIS;   LCIS
Intervention:   Radiation: MRIdian Radiation Treatment Unit
Sponsor:   University of Wisconsin, Madison

Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors
Published: 27 Mar 2019 | 16:00 UTC

Conditions:   Advanced Digestive System Neuroendocrine Neoplasm;   Digestive System Neuroendocrine Tumor;   Foregut Carcinoid Tumor;   Hindgut Carcinoid Tumor;   Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm;   Metastatic Digestive System Neuroendocrine Neoplasm;   Midgut Carcinoid Tumor;   Pancreatic Neuroendocrine Tumor;   Refractory Digestive System Neuroendocrine Neoplasm
Intervention:   Drug: Abemaciclib
Sponsors:   University of Washington;   National Cancer Institute (NCI)

Loratadine for Improvement of Bone Pain in Patients With Chronic Granulocyte-Colony Stimulating Factor (G-CSF) Use
Published: 20 Mar 2019 | 16:00 UTC

Condition:   Bone Pain
Interventions:   Drug: Loratadine;   Drug: Placebo
Sponsor:   University of Michigan

A Study to Evaluate the Long-term Safety and Efficacy of Fenebrutinib in Participants Previously Enrolled in a Fenebrutinib Chronic Spontaneous Urticaria (CSU) Study
Published: 3 Oct 2018 | 16:00 UTC

Condition:   Urticaria
Intervention:   Drug: Fenebrutinib
Sponsor:   Genentech, Inc.

Exploratory fMRI Study on the Treatment for Impulsive Aggression in Children With ADHD
Published: 20 Aug 2018 | 16:00 UTC

Condition:   Attention Deficit Hyperactivity Disorder (ADHD)
Interventions:   Drug: SPN-810;   Drug: Placebo
Sponsor:   Supernus Pharmaceuticals, Inc.

Echinacea Angustifolia (AnxioCalm) in Anxiety
Published: 13 Mar 2018 | 16:00 UTC

Condition:   Generalized Anxiety Disorder
Interventions:   Dietary Supplement: Echinacea angustifolia;   Dietary Supplement: Placebo
Sponsors:   EuroPharma, Inc.;   Simon Khechinashvili University

Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures
Published: 9 Feb 2018 | 17:00 UTC

Condition:   Pain, Postoperative
Interventions:   Drug: 30 mg Paracetamol 3% (1 mL);   Drug: 60 mg Paracetamol 3% (2 mL);   Drug: 90 mg Paracetamol 3% (3 mL);   Drug: Placebo, 0.9% saline solution;   Drug: NIMP: Chloroprocaine HCl 1% (10 mg/mL), solution for injection
Sponsors:   Sintetica SA;   Cross Research S.A.

Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia
Published: 18 Aug 2016 | 16:00 UTC

Condition:   Primary Ciliary Dyskinesia
Interventions:   Drug: VX-371;   Drug: Hypertonic Saline;   Drug: Placebo (0.17% saline);   Drug: Ivacaftor
Sponsors:   Vertex Pharmaceuticals Incorporated;   Parion Sciences

A Study of Nab-Paclitaxel and Carboplatin Plus Necitumumab (LY3012211) in Participants With Stage IV Squamous NSCLC
Published: 19 Mar 2015 | 16:00 UTC

Condition:   Carcinoma, Non-small-Cell Lung
Interventions:   Drug: Necitumumab;   Drug: Nab-Paclitaxel;   Drug: Carboplatin
Sponsors:   Eli Lilly and Company;   Celgene

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